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Gail Henderson is a medical sociologist
with training in public health. Her teaching and research interests include
global health inequality and research ethics. She has extensive experience
with qualitative and quantitative data collection and analysis, as well
as conceptual and empirical cross-disciplinary research and analysis.
She is the principal investigator (collaborating with Nancy King and others)
of an NHGRI ELSI grant that examines how benefit in gene transfer research
(GTR) is discussed and understood by those who conduct and participate
in
GTR trials. Results of this study have identified factors associated with
the therapeutic misconception in GTR, including vague or misleading information
in consent forms, difficulty faced by IRBs in reviewing benefit, and lack
of clarity in how the nature and likelihood of direct benefit in GTR is
described by all research participants. More information about this study
is available on their project
website.
Henderson is also co-investigator with Giselle Corbie-Smith on an ELSI
grant that
surveys participants in a case-control study of colorectal cancer in
blacks and whites in North Carolina. This project seeks to determine the
perceptions of genetic research and collection of genetic data, and whether
these perceptions vary by disease status or race/ethnicity.
Along
with a number of other CCGS faculty, Henderson is also an investigator
for the recently awarded Center for Excellence in ELSI Research (CEER)
planning grant. This three-year grant examines the ELSI issues arising
in three unique projects at UNC-CH that involve large-sample gene
discovery and disclosure. The goals are to develop an infrastructure to
maximize
collaborative research, create partnerships with relevant constituencies,
identify critical issues, and collect sufficient pilot data to propose
a well-integrated center in which state-of-the-art ELSI research can
be conducted to inform public policy. More information about the planning grant can be found in this
article and at the Center for Genomics and Society website. Selected Publications: Henderson GE, Easter MM, Zimmer C, King NM, Davis AM, Rothschild BB, Churchill LR, Wilfond BS, Nelson DK. (2005) Therapeutic misconception in early phase gene transfer trials. Soc Sci Med. Jul 4; [Epub ahead of print]. Henderson GE, Davis AM and King NMP (2004) Vulnerability to influence–a two-way street. Invited commentary on “The limitations of vulnerability as a protection for human research participants.” Levine C, Faden R, Grady C, Hammerschmidt D, Eckenweiler L and Sugarman J. Am J Bioeth 3:50-51. Henderson GE, Davis AM, King NMP, Easter MM, Zimmer CR, Rothschild BB, Wilfond BS, Nelson DK and Churchill LR (2004) Uncertain benefit: investigators’ views and communications in early phase gene transfer trials. Mol Ther 10:225-231. Churchill LR, Nelson DK, Henderson GE, King NMP, Davis AM, Leahey EE and Wilfond BS (2003) Assessing benefits in clinical research: why diversity in benefit assessment can be risky. IRB 25:1-8.
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contact information: [phone] [email] |
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